5-FU 5-fluorouracil
[6R]-MTHF Modufolin®
5-dTMP 5′-monophosphate
5-FU/LV A commonly used combination treatment consisting of 5-fluorouracil and leucovorin
ABCC3 Canalicular multispecific organic anion transporter 2
CRC Colorectal cancer
DFS Disease Free Survival
dUMP methylation of deoxyuridine-5′-monophosphate
FDA U.S. Food and Drug Administration
FOLFIRI A chemotherapy regimen made up of: FOL – Folinic acid (leucovorin), F – fluorouracil (5-FU) and IRI – Irinotican (Camptosar)
FOLFOX A chemotherapy regimen made up of : 5.fluorouracil, oxaliplatin and leucovorin
FPGS Tetrahydrofolate synthase
GGH Gamma-glutamyl hydrolase
GMP Good manufacturing practices (GMP) are the practices required in order to conform to the guidelines recommended by agencies that control authorization and licensing for manufacture and sale of food, drug products, and active pharmaceutical products.
HDMTX High doses of Methotrexate
i.v. Intra venous (injection)
IND Investigational New Drug Application (for the FDA, US Drug Agency)
LC–MS/MS Liquid chromatography-mass spectrometry / mass spectrometry
LLV Levoleucovorin
LV Leucovorin
Modufolin® Chemical name [6R]-5,10-methylenetetrahydrofolate, a novel folate-based compound developed to increase the efficacy and reduce the side effects of antimetabolites used in cancer treatment. It is the key active metabolite of all clinically used folate-based drugs today including leucovorin and levoleucovorin and therefore does not require metabolic activation.
MPA Swedish Medical Product Agency
MTHF 5,10-methylenetetrahydrofolate
MTX/HDMTX Methotrexate / High Dose Methotrexate
ORR Overall Response Rate
PCFT Proton-coupled folate transporter or solute carrier family, member 1(SLC46A1)
PFS Progression Free Survival
PK/PD Pharmacokinetics / Pharmacodynamics
SHMT-1 Serine hydroxymethyltransferase
THF Tetrahydrofolate
TS Thymidylate synthase